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Regional Brain Abnormalities in Schizophrenia Measured with Magnetic Resonance Imaging
JAMA 272:1763-1769, Andreasen,N.C.,et al, 1994
See this aricle in Pubmed

Article Abstract
In addition to the generalized brain abnormalities observed in schizophrenia,a regional abnormality may be present in frontal regions. Since the frontal lobes integrate multimodality information and perform a variety of"higher"cognitive and emotional functions that are impaired in schizophrenia,the frontal abnormality noted is consistent with the clinical presentation of the illness.Impaired frontal function and disruption in its complex circuitry(including thalamocortical projections) may explain why patients with schizophrenia often have significant deficits in formulating concepts and organizing their thinking behavior.
 
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frontal lobe,anatomy and physiology
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